The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities
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چکیده
منابع مشابه
The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.
Hepatitis C (HCV) protein 3/4A (NS3/4A) is a bifunctional enzyme comprising two separate domains with protease and helicase activities, which are essential for viral propagation. Both domains are stable and have enzymatic activity separately, and the relevance and implications of having protease and helicase together as a single protein remains to be explored. Altered in vitro activities of iso...
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The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently.
The nonstructural 3 (NS3) protein encoded by the hepatitis C virus possesses both an N-terminal serine protease activity and a C-terminal 3'-5' helicase activity. This study examines the effects of the protease on the helicase by comparing the enzymatic properties of the full-length NS3 protein with truncated versions in which the protease is either deleted or replaced by a polyhistidine (His t...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2013
ISSN: 0961-8368
DOI: 10.1002/pro.2378